سایرتحقیق و پژوهش

نحوه ارسال مقاله برای چاپ و فرایند چاپ

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‎oe‏ برای چاپ و فرايند جاب ‎ ‏بن جانقربانى ‎٠‏ اپیدمیولوژی

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مراحل آماده ۱ نام

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وت

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5 ارسالی ۸۵ 5316۳06۳01 0۴ 0۸۵۳۱61۵1 ٩ ۲ relationships that might lead to a conflict of interest, if that information is not included in the manuscript itself or in an authors’ form. _ Astatement that the manuscript has been read and approved by all the authors, that the requirements for authorship as stated earlier in this document have been met, and that each author believes that the manuscript represents honest work if that information is not provided in another form.

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5 ارسالی _ The name, address, and telephone number of the corresponding author, who is responsible for communicating with the other authors about revisions and final approval of the proofs, if that information is not included in the manuscript itself.

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ارسالی _ Many journals now provide a presubmission checklist to help the author ensure that all the components of the submission have been included. Some journals now also require that authors complete checklists for reports of certain study types (for example, the CONSORT checklist for reports of randomized, controlled trials). Authors should look to see if the journal uses such checklists, and send them with the manuscript if they are requested.

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ارسالی _ Letters of permission to reproduce previously published material, use previously published illustrations, report information about identifiable persons, or to acknowledge people for their contributions must accompany the manuscript.

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ارسال با پست هوایی

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‎ae‏ 0 و رد سور ‎

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و تصمیم ها و پاسخها گ و مشروط

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کم ار ول » نگارش و نهر یک مقالد در باب پیام مقاله تصمیم بگیرید. در باب این که آیا اصولا مقاله به نوشتن می ارزد یا خیر» تصمیم بگیرید. ۰ اهمیت مقاله تصمیم بگیرید. محک " چه حاصل؟ " را بد. 5 در باب مخاطبان مقاله تصمیم بگیریدد محک " " چه کسی توجه خواهد كرد؟ رابه کار ببندید. ای که مقاله را برای نشر در آن مهيا خواهيد کرد. بركزينيد. به جستجوى متون و آثار بيردازيد ۷ ره نويسندكان تصميم بكيريد.

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مواد 0 برای نگارش و سرانجام. نشر مقاله را فراهم آورید. ار س0 رح مقدماتى رئوس مطالب ‎٠‏ ساختار كامل مقلله 000 ون گاه نگارش پیش نویس را آغاز Le ‏مقدماتی از رئوس مطالب تهیه کنید.‎ ‏نخستین پیش نویس را بنویسید.‎ در نخستین پیش نویس و پیش نویس های بعدی (به کمک هر ‎Be‏ 0 همکار) تجدید نظر کنید تالن که محتوای مقاله رضایت خاطر شمارا فراهم کند. پرای رسیدن به درستی » روشنی ۰ گوتاهی و دلپذیری کلام » به یازنگری نثر و شیوه نگارش خود بپردازید.

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اطمینان حاصل کنید که جزئیات شیوه علمی را بدرستی رعایت کرده اید. بهترین حالت و شیوه ارائه جدولها و تصویرها را برگزینید. درصورت لزوم آخرین پیش نویس کامل را بازنگری و مرورکنید و آن را برای تهیه دستنوشته نهایی به ماشین نوبس بسپارید. نسخه هایی ازدستنوشته و مواد وابسته ای را که قرار است به پیوست نامه ارسالی برای سردبیر مجله بفرستید. فراهم آورید. به تصمیم سردبیر پاسخ دهید. مقلله ای را که مشروط پذیرفته شده طبق خواسته مجله بازنگری کنید. مقله ای را که پذیرفته نشده » پس از بازنگری لازم بای مجله ایک ارسال دا ۱ ار ‎Sos (Eide‏ بردارید. اگر مقاله ای برای انتشار پذیرفته شد. به محض دریافت نموثه چاپی به تصحیح ‎BT‏ بپردازید. بسرعت آن را باز پس فرستید و منتظر نشر مقاله شوید.

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Mayer B. Davidson, M.D. Editor-in-Chief, Diabetes Care 6919 E. Tenth Street, Suite B-2 Indianapolis, IN 46219 27 March 2006 Dear Prof. Davidson; Thank you very much for your email and referees’ comments dated 16 March 2006 regarding our manuscript (DCO6-0440R “PROSPECTIVE STUDY OF DIABETES MELLITUS AND RISK OF HIP FRACTURE: THE NURSES’ HEALTH STUDY"). We attach a revised manuscript taking into account the reviewers’ comments as follows: Reviewer A Comments: This is a well done study with appropriate analyses and conclusions. Having so large a study group enables you to have an adequate sample of diabetic patients to do a strong analysis. You make a valid point that fracture prevention is an important part of the care of women with diabetes. Reply: Thank you very much.

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Reviewer B Comments: This is a well-written fine article about the association between type 1 and 2 diabetes mellitus and risk of hip fracture. The authors present a conclusion that both type 1 and type 2 diabetes increase the risk of hip fracture in women. Although the authors emphasize the advantages of their huge sample size, there is however a danger of false positive finding in such a large cohort. Although the cohort was originally not planned to study hip fractures, and the authors were not there to perform any power calculations in the beginning, did the authors calculate how many women they would need to show the clinically and statistically significant difference in the rate of fractures and risk ratios? | suggest the authors remove the conclusion concerning the duration of type 2 diabetes from the conclusion section, page 13 (In summary, our...) as they have done in the abstract section. This conclusion can not be drawn due to the probably high frequency of undiagnosed type 2 diabetics. The finding is interesting but may not be included in the final conclusions. Reply: We acted on suggestion made by reviewer B and removed the conclusion regarding duration of type 2 diabetes from the conclusion section of Discussion. About sample size, this study is one of the largest cohort studies to date of a relationship between diabetes and risk of hip fracture. Regarding power analysis, on the basis oF previous estimates of hip fracture incidence of 1%, we calculated that 1,225 wemen with type 2 diabetes and 12,250 women without diabetes would be required to pfoyide: the stildy with 80 percent power to detect (with a two-sided alpha of 0.05) a felative risk of hip fracture in type 2 diabetes 2.0. Regarding power analysis in type 1 digbetes, on the basis of post hoc estimates of relative risk of 6.0 for type 1 diabetes, we calculated that 84 women with type 1 diabetes and 5,796 women without diabetes would be required to provide the study with 80 percent power to detecti(with a two- sided alpha of 0.05) a relative risk of hip fracture in type 1 diabetes 6.0, We did not Gar iicia these aware calianae Boealien Paeebatictical uncertainty ‏حم و اس کی‎

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Reply: We have added the following in the Results section to describe the mean age of women at the time of hip fracture: The mean (SD) age of hip fracture was 65.6 (8.3) years for nondiabetics, 65.3 (7.4) years for type 1, and 68.6 (7.2) years for type 2 diabetes. Comment- Abstract: Typo error in "Research design and methods" (desighn) Typo error in "Results": ..the age adjusted relative risk...(risks). Reply: The English editing has been done. Comment- Introduction: Please be more careful when referring to previous studies. There are several mistakes in the references. For example, it is said in the Introduction section, first paragraph, line 12, that: ...whereas others reported no association (...23), but in the Discussion section, page 9, line 8, the same reference (23) is quoted ...type 1 diabetes was associated with increased risk of proximal humerus fractures. In the Introduction, line 13, reference 25 is quoted as ..."whereas others reported no association or even an inverse relation (..25). In fact, the results in SOF revealed that the women with diabetes were at increased risk of intra-articular radial fractures, not decreased. Furthermore, in the Introduction, line 9, the reference 21 is not in the right place. Ref 21 is a study which showed an inverse association between type 2 diabetes and bone mass and fractures, not type 1 diabetes and fractures. | suggest the authors remove the Ref 21 from the line 9, and change the places of Ref 25 and 21 in the lines 12 and 13. Furthermore, | suggest the authors concentrate on their literature review more on studies that have evaluated the association between diabetes and hip fractures, not on wrist or other minor fractures. The authors state that the samples in the previous studies have been small, but for example the Swedish cohort

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Reply: We acted on suggestion made by reviewer B and corrected the references accordingly and removed sentences indicate previous studies have been small. Comment- Important risk factors for hip fracture include risk factors of falling, for example balance disturbances, muscle function, functional ability, walking ability, walking speed etc. Did the questionnaires include any questions about self rated mobility, balance, muscle strength, difficulties in daily activities, difficulties in ADL or IADL due to impaired vision, fear of falling, fall history etc. If not, | suggest these will be include in future questionnaires. Reply: Unfortunately, in our database information about self rated mobility, balance, muscle strength, difficulties in daily activities, difficulties in ADL or JADL due to impaired vision, fear of falling, fall history etc. was not recorded at baseline. Some of this has been collected in more recent questionnaires and, with additional follow-up, will serve as the basis for future analyses. Comment- Analysis: At what stage and why did the authors classify the duration of type 2 diabetes into three classes? Why did you not handle the duration as a continuous ‏تس‎ Reply: The classification of duration of diabetes was done 2 examination of the distribution of duration to have an adequate nung 4 person-time in each category. We believe a categorical analysis is useful because it conveys information about the actual distribution of duration in our study and also the corresponding relative risks. The analysis was als0 performed with duration of diabetes as continuous covariate amt the result was similar. The P for trend is the analysis with duration of diabetes as a

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Comment- Results: In the Abstract, Results section you mention the years (>=12 years), but not in the text, Results section, page 8, where you state that "Women with longer duration of type 2 diabetes tended to...". Please be more precise also in the text. The abstract should be a summary of the text. In the Results, Incidence section, please refer to the Table 2. Reply: We have made the amendment according to the suggestion and the following sentence addressed in Results section: “Women with longer duration of type 2 diabetes tended to have a higher risk of fracture than did diabetics with a shorter duration (RR 3.1; 95% Cl 2.3, 4.0, for =12 years compared to no diabetes, P for trend <0.001)". We also referred to Table 2 in the Incidence section of Results. Comment - Conclusions, page 11, 3rd paragraph: | think the readers would appreciate more profound discussion about the possible explanations concerning the association between insulin treatment and increase risk of hip fractures. Does insulin not have an osteogenic effect as previously suggested? Reply: We have made the amendment according tothe suggestion.Comment- Conclusions, last page: The sentence ‏وه‎ ‎summary, our..." is not clear. | Would suggest "In summary, ougstudy indicates that women with type 1 or type 2 diabetes are at increased, risk for hip fracture."Reply: We have made the changes according to the suggestion. We thank this reviewer for his/her careful reading of our manuScript and constructive siiggestions. =

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These are further data based on the large prospective observational Nurses' health study. This study had provided lots of valuable information re women's health. Most of the participants are Caucasian but this acknowledged by the authors. The paper is very well written and easy to understand. It sends an important message to clinicians caring for people with diabetes. We rightly spend a lot of time and effort reducing macrovascular/renal/visual/foot complications but don't think that much about preventing the morbidity and mortality (and expense) due to fragility fracture. This may be because many diabetologists don't "do bones"! However, the RR for hip fracture shown here for type 1 diabetes is greater than most other recognized independent risk factors used to predict risk of fragility fracture. The study also demonstrates the increased risk in Type 2 diabetes. This is also an important clinical point. Many health care professionals tend to think that fracture risk just relates to bone density, which in people with type 2 diabetes is often not low enough to classify as osteoporosis. However most fractures occur in individuals with osteopenia (not osteoporosis) - hence the importance preventing fragility fracture by assessing and reducing falls risk in our patients with reduced vision and neuropathy. Preventing fragility fracture is like managing diabetes — it’s about education and interdisciplinary collaboration. Diabetologists should be good at it. This paper will hopefully encourage clinicians to prevent yet another unpleasant complication Reply: We thank the reviewer for his/her advice. سر لسن (۰ ‏اج‎ PHD Prob. oP ‏وال‎ Orr oP ‏مس(‎ Aarverd Ocho! oP Pubhe Wells 88S 1 vets Decne, Over DOMIS Pe 52021۳0-0000

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6919 E. Tenth St., Suite B-2 Indianapolis, IN 46219 February, 2006 of ;Dear Prof. Davidson Please find enclosed a copy of a paper entitle “PROSPECTIVE STUDY OF DIABETES MELLITUS AND RISK OF HIP FRACTURE: THE NURSES’ HEALTH STUDY” for publishing in Diabetes Care. | takes full responsibility for the data presented in this study, analysis of the data, conclusions, and conduct of the research. | had full access to data and has maintain the right to publish any and all data independent of any third party. The Ethical Review Committee of Harvard School of Public Health and Brigham and Women’s Hospital approved the study protocol. | confirm that neither the manuscript submitted nor any part of it has been published or is being considered for publication elsewhere .Would you please consider it for publication and let me know your decision .Thank you very much in advance ;Sincerely yours M. Janghorbani, PhD Prof. of Epidemiology. Dept. of Epidemiology and Biostatistics School of Public Health Isfahan University of Medical ‏وزج‎

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جناب آقای دکتر عزیزی سردبیر محترم مجله پژوهش در پزشکی با سلام محترماً؛ به پیوست یک نسخه از مقلله ای تحت عنوان »اعتبار سنجش های تن سنجی در تشخیص نوزادان کم وزن« جهت چاپ در آن مجله ارسال می گردد. خواهشمند است دستور فرمایید پس از بررسی های لازم اینجانب را از ضمنا لين مقلله منحصراً جهت جاب در آن مجله نوشته شده و تاکنون در جایی ‎Ole‏ نرسیده يا جهت چاپ دردست بررسی نمی باشد و تا دریافت ياسخ ‎١‏ مرتعالى قصذ انتشار أن را در سایر ۲ ۱۱ ۱۲ قبلااز بذل توجه حضرتعالی سپاسگزارم. با احترام دکتر محسن جانقربانی استاد اپیدمیولوژی

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جهت مطالعه ادامه متن، فایل را دریافت نمایید.
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