بروسلوزیز (brucellosis)

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IN THE NAME OF GOD Brucellosis Reza Yavari 

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Introduc tion: Brucellosis is one of the most prevalent bacterial zoonotic diseases causing significant economic losses due to the livestock abortion, and also it is possibly a life-threatening multi-system disease in Human. 

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Etiology: 1. Small 2. Gram negative 3. Intracellular 4. Non motile 5. Non sporulating 6. Non toxigenic 7. Non fermenting 

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Table . Clsifeton of Brucella sp pathogens Endemic Mt Brucella Host Pathogen Number Binars isolated in blovarsin prevalent Hosts ‘species preferences potential of biovars. in Iran" ‏الصا لس‎ ‏ور كسمي بولك‎ 8 ‏مرا‎ high 3 123 1 1 camel, dog “om ‏ات له‎ Cal B.aborms Came modems = 7 123,4,5,649 3 ‏وعم کرد‎ snd goat Bais Panes ‏و یی‎ 1 4 ۰ Pg Bos ‏مساو‎ low 1 2 3 ‏لسع‎ Dogs . 1 “ 2 . 2 Deset wood ‏سر‎ 7 ۰ 1 . 2 2 ۳ 8 ‏السامماسم‎ Seals 0 2 2 * 4 2 ‏اسلمة‎ تسسصلع‎ = ۰ ۰ ۰ ۰ ۰ Beet ‏قشم‎ aw . - - s Wi odent رما ۵ 

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Epidemiol ogy: Annually, more than 500,000 new human cases of brucellosis are reported worldwide The prevalence rates of brucellosis are more than 10 cases per 100,000 population in some countries. 

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۱ Tac of Brac per ‎Prints an‏ سل ‎a ppt‏ ‎Lost‏ 0[ ‎emumhh, Wt acu Souh Khas i‏ نز ‎High Kort, airy, an Zu 130‏ ‎Gola, an, Quin, Sema, Cima snd‏ ۵ لا بسا تا ابا تا ‎Mite‏ ‎Nor Koran Furs‏ ‎Baste, Khuesun, Kobgiych and. Boye Low ‏سا ام ما با اسلا‎ isn ۳ ‎rey 

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Transmission & risk factors : The prevalence of human brucellosis is dependent upon factors such as husbandry as well as environmental sanitation . Brucellosis is transmitted from infected livestock to human via 

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Clinical manifestations : Acute brucellosis Sub-acute brucellosis Chronic brucellosis 

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Microscopic examination of stained smears is a useful tool for probable diagnosis, especially if it is confirmed by other tests. Diaégnos iss COOMB 08 ۱ ‏اه تب ی کت‎ ۳ ——<$ IgG Soe ۳ IgM 

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Treatment : Despite the application of WHOs antibiotic regimen recommendation , which consists of doxycycline 100 mg orally twice a day for 6 weeks plus oral rifampicin 600 to 900 mg daily for 6 weeks or streptomycin 1 g intramuscularly daily for 2_3 week . the rate of brucellosis treatment failure and 

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رد ‎Brucella bacteria is usually‏ ۳ ۱ 1 ‎transmitted to humans by‏ ۱ ‎contact with infected‏ 1 ۳ _ ,۷ | 

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Prevention : رت ۱3 * prevent Brucella infection in both genders * not provoke disease in immunized animals ‏الا‎ * confer long-term protection ae only one dose _* not interfere with LPS-based serological tests aX) ‏کایرت‎ ممصملنزه گه علعزد مطا دهعتم امد هصح ملطفاه برللهءزوه[0ز ‎Not be pathogenic to humans‏ * ‎the vaccinated animals‏ 3 ۱ ۷ i Ga cee 

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Control and Eradication : Identification of infected animals WHO IINITORING Herds & regions suggested: faccination 

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Consumption of unpasteurized milk and dairy products and also raw or undercooked animal products (including bone marrow) should be avoided 

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Referen ce: A Review of Brucellosis in Iran: Epidemiology, Risk Factors, Diagnosis, Control, and Prevention Maryam Golshani and Saeid Buozari* Department of Molecular Biology, Pasteur Institute of 

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QUESTIO N? CM) FG OE we 

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