مسیر پیام رسانی سلولی TGF-B

مسیر پیام رسانی سلولی TGF-B

اسلاید 1: TGF Beta Signaling PathwayBy : Behnaz Bazrafshan

اسلاید 2: INTRODUCTIONCells communicate with : membrane-associated proteinsSecreted moleculesWhy cell needs to contact ? ProliferationDifferentiationMetabolismBehaviour

اسلاید 3: IMPORTANCE Of TGF-Beta Signaling PathwayAmong the secreted growth factors and cytokines, the transforming growth factor–b (TGF-b) family receives a lot of attention because of its many functions at the cellular level and in development and its roles in many diseases including cancer.

اسلاید 4: Function of TGF Beta Pathway in Normal CellsPattern formation during embryonic developmentCell growth and proliferationCellular differentiationExtracellular matrix productionAngiogenesisTissue repairImmune regulationApoptosis

اسلاید 5: PROPERTIESSecretedfunction as homodimers or heterodimersstimulate cell proliferationstrongly inhibits the proliferation of various cell typespromote or protect against cell deathpromote extracellularmatrix (ECM) protein expressioncell motility and invasioncontrol cell metabolism