پزشکی و سلامتسایرتحقیق و پژوهشطب سنتی

Examination Issues in Natural Products

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‎Examination Issues in‏ عد ‎rN Natural Products‏ ‎ ‎Brenda Brumback ‎SPE Art Unit 1654 ‎= ‎

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Greece Middle East India

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Europe In the beginning of the 18" century, Swedish Botonist Carl Linnaeus developed the Latin Botanical Classification system. * Kingdom * Phylum * Class * Order * Family * Genus * Species

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Vf EK United States Native Americans passed along medicinal knowlediit of indigenous plants to the early MMi ‏للا‎ ۸0۲۱02 0 EA ES

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Herbal Medicines in U.S. Patents 424/725-779: Plant material or plant extract of undetermined constitution as active ingredient (e.g., herbal remedy, herbal extract, powder, oil, etc.). 514/783: ° Plant extract or plant material of undetermined constitution.

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Prosecution of Plant Extract (Herbal) كحته توح خلويو سس Restriction: A Markush group of plant extracts recited in a claim should be limited to extracts derived from plants of the same botanical family or genus. Claims that alternatively recite a large number of extracts derived from plants that have little in common are likely to be subject to a restriction requirement.

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Idiomatic Language *“Ginmei” (golden stripes on green-culm or stalk) *“Invigorates Qi” *“Expels heat from heart”

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2 Claim Language The correct botanical name (Latin Botanical) is written in italics with the genus name capitalized, and the species name all in lower case.

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Botanical Nomenclature * Harpagophytum procumbens, also known as devil’s claw, grapple plant creosote bush, greasewoo} مه neem and also known as n : ume ta * Larrea divaricata, also known as ne * Azadirachta indica, commonly known as 7

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۱ Products of Nature are not Patentable under iN 35 U.S.C. 101 SSS A composition comprising phytoc”

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An Enabling Disclosure * It is important to sufficiently describe how to make and use the claimed extract or material. * The part/parts of the plant used * The plant name/names * The type/types of solvent used + Extraction temperature and pH * Material used fresh or dried and/or chopped or powdered * Separation/fractionation/recovery/isolation steps

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The particular part of the plant from which the extract is obtained is often essential. fe Roots/rhizome/bulb: asparagus, beet, garlic, ginseng, Narcissus, Polygonatum Leaves: aloe, Barosma, Betula, Camellia, Cassia, Ginkgo, Prunus Jaurocerasus Bark: Canella, poplar, Prunus serotina, Quercus robur Flower: Artemisia, Arum, Prunus spinosa Fruit: Barberry, Vaccinium, Sorbus, Pyrus, Rhamnus 7

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‎Drafting Claims to a‏ عد ‎TN Plant Extract‏ ‎ ‎° Product-By-Process Claims ‎Herbal extracts are prepared with: * Water ‎* Polar solvents ‎* Non-polar solvents ‎* Acids ‎* Bases

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Examples of preferred claim language RS ٠ An alcoholic extract of Narcissus bulb. » An aqueous extract of a Palma fruit. ° A hot water extract obtained from the dried leaves of Nepeta cataria. * An extract from chopped fresh roots of Harpagophytum procumbens, whereby the extract is obtained using a non-polar solvent.

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Anticipation under 35 U.S.C. 102 Webster’s dictionary defines ‘extract’ as follows: 1a: to draw forth (as by research) <extract data> b : to pull or take out forcibly <extracted a wisdom tooth> c: to obtain by much effort from someone unwilling <extracted a confession> 2 : to withdraw (as a juice or fraction) by physical or chemical process; a/so: to treat with a solvent so as to remove a soluble substance 3 : to separate (a metal) from an ore 4: to determine (a mathematical root) by calculation 5 : to select (excerpts) and copy out or cite.

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‎Plant Extracts are‏ عد ‎Ubiquitous‏ \7 ‎* An extract of Coffea arabica: Coffee ‎*An extract of Camillia sinensis: Tea ‎*An extract of broccoli: Soup *An extract of orange: Orange juice ‎

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Obviousness under 35 U.S.C. 103 As set forth in In re Kerkhoven, 626 F.2d 846, 850, 205 U.S.P.Q. 1069 (CCPA 1980), “It is prima facie obvious to combine two compositions each of which is taught by the prior art to be useful for the same purpose, in order to form a third composition which is to be used for the very same purpose...the idea of combining them flows logically from their having been individually taught in the prior art”.

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Searching the Prior Art * Arbre aux quarante ecus (forty coin tree) + eun-haeng (fossil tree) + ginan + Icho موز« + kew tree + maidenhair tree موسوم« ٠ Pterophyllus salisburiensis Nelson « Salisburia adiantifolia Smith + Salisburia macrophylla C. Koch + temple balm + tempeltrae « yin guo + yinhsing + olium ginkgo + Ginkgo folium ... gin-nan + ginkgoblatter * ginkgo balm ‘Ginkgo biloba

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‎Useful Databases for‏ عد ‎YN Searching Herbals‏ ‎ ‎» Chinese Traditional Medicine ‎» PROMT on STN ‎» NAPRALERT on STN

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