عوارض جانبی داروهای گوارشی

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گروه فارماکولوژی 

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0 ( ۳ ۱ 

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Ranitidine ‏[دد02؟ أومغمع هم باط لاالمتهصم) كاعع525 عورع‎ Effects on the cardiovascular system:. Bradycardia, AV block and cardiac arrest has been | lol Also.a +ve inot Effects on the endocrine system: gynaecomastia, loss of libido, and impotence less than cimetidine - 

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Effects on the nervous system: confusion, loss of color vision, aggressiveness, lethargy, somnolence, disorientation, depression, hallucinations and ‎hepatotoxicity‏ ا مه ‎ ‎ 

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2 15 1 ‏كك"‎ ltetey site(s Effects on the cardiovascular system: 40 mg daily by mouth reduced cardiac output and stroke volume. Also bradycardia and AV biesichan hnererepertad system: transient hyperprolactinaemia and glactorrhoea Effects on the nervous system: convulsions and mental deterioration in elderly patients with renal failure, 

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t extent, and therefore isidered to have lit the metaboli: 

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Nizatidine Adverse Effects Effects on the cardiovascular system: has been reported to reduce heart rate, also tachycardia, bradycardia, orthostatic hypotension and syncope arely with rapid intravenous ‏ای‎ 

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isolated repor gynaecomasti 

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Pomp Inhib (PPIs) Omeprazole aa 0 Lansoprazole Pen Rabeprazole Pantoprazole ۳ 1 OOH ۳ ۳ از ا ITH NIT 

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Omepraz Side effects — 1 of the most frequent side effects of omeprazole are; headache, diarrhea, abdominal pain, nausea, awakening « hip fractures tal [okt tridium 

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(pantoprazole can cause a false positive for THC) 

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. Lansoprazd@le effects dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus taste disturbanc lysfunction, peripheral oedema, hypersensitivity reactions Gastro-intestinal disturbances (such as nausea 1.3%, abdominal pain 2.1%, diarrhea ic sD) 

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... ۵۳06۵0۲۵2۵۵ 66 e most common is headache in 2.4% of patients Diarrhea, vomiting, nausea, abdominal pains, Constipation, meteorism, dry mouth, increased or decreased appetite, asthenia, anxiety, vertigo, Sleeplessness, thrombocytopenia, 

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Cisapride SF 7 2 shoe cage col yt gl gio cyl 0411/17 ‏تحريك كيرنده هاى 1114-4 و افزايش‎ 

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.. Domperidongdverse Effects galactorrhoea or aecomastia: plasma prolactin - Effects on parenteral prod 

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Colpermin ‏ارصرىرىپآپسصپ ينا‎ Indications And Clinical Uses: flatulence and gas associated with the irritable bowel syndrome (IBS). 

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.. Colpermin Adverse Reactions: Reactions may ‏هو‎ heartburn and ‎to orale oil or‏ الال أكمع دعم لاط ‎menthol, miter is rare 200 includes‏ ‎erythematous 50 headache,‏ ‎bradycardia, muscle tremor and ataxia Not to be used in Children under 15 years of age 

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Misoprostol Adverse Effects 

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mcr seen at doses ۲ peptic ulcer di 

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Antacids Side effects from antacids vary depending on individual and other ‏تحت یب‎ Those who experience side effects most commonly suffer from changes in bowel functions, such as diarrhea, constipation, or flatulence. 

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.. Antacids Milk-alkali syndrome, which is serious Coy and can be fatal Aluminum MOA insoluble aluminium-phosphate- complexes, with a risk for hypophosphatemia and INcsi ae) lo) ‏ك5‎ Po) 

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7 meer Grrr tl tps + 2HCI — MgCl2 + 2H20 

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Laxatives (also known as purgatives or aperients) Laxative Abuse: — occurs when a person attempts to salories, lose laxative abuse Is Serious and dangerous, often resulting in a variety of health complications and sometimes causing و و و ۱۱۱۱ دن كا 

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ith consequences of laxative abuse Upset of electrolyte and mineral balances. pest) Sat ae ube ay Cause tremor: vision, fainting, extreme cases, Internal organ damage may result, including stretched or “lazy” colon, colon infection, Irritable Bowel Syndrome, and, rarely, liver damage. Chronic laxative abuse may contribute to 0] eln ‏و‎ ignesium, and akness, blurry damage, and, in 

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عوارض جانبی داروهای گوارشی دکتر محمد طاهر بروشکی گروه فارماکولوژی دانشکده پزشکی مشهد 1389 گروههای دارویی آن)تیک))ول)ینرژ)ی)کها -H2ب))لوکرها مهار کننده های پمپ پروتونآنتی اسیدها ملین ها آنتی کولینرژیکها داروهای پروکینتیک کلپرمین Histamine H2-Antagonists H2- Blockers مصرف از راه خوراكي،عدم عارضه جانبي مهم به جز سايمتيدين: ژينكوماستي (دوز باال) كاهش قواي جنسي در مردان (تغيير در متابوليسم استروژن) ،مهار آنزيمهاي سيتوكروم Unlike cimetidine, ranitidine does not seem to affect cytochrome P450 to any great extent, and therefore is considered to have little Ranitidine verse Effects (mainly by parentral forms) Effects on the cardiovascular system:. Bradycardia, AV block and cardiac arrest has been reported . Also a +ve inotropic effect. Effects on the endocrine system: gynaecomastia, loss of libido, and impotence less than cimetidine ….. Ranitidine Effects on the nervous system: confusion, loss of color vision, aggressiveness, lethargy, somnolence, disorientation, depression, hallucinations and severe headache, ects on the liver: hepatotoxicity Famotidin e Adverse Effects Effects on the cardiovascular system: 40 mg daily by mouth reduced cardiac output and stroke volume. Also bradycardia and AV block reported system: Effectshas on been the endocrine transient hyperprolactinaemia and glactorrhoea Effects on the nervous system: convulsions and mental deterioration in elderly patients with renal failure, Nizatidine Unlike cimetidine, nizatidine does not seem to affect cytochrome P450 to any great extent, and therefore is considered to have little effect on the metabolism of Nizatidine Adverse Effects Effects on the cardiovascular system: has been reported to reduce heart rate, also tachycardia, bradycardia, orthostatic hypotension and syncope have been reported rarely with rapid intravenous injection Some patients taking nizatidine may experience excessive sweating and urticaria; anaemia may also occur ….. Nizatidine Nizatidine is considered to have little or no anti-androgenic activity although there are isolated reports of gynaecomastia and impotence Proton Pomp Inhibitors (PPIs) Omeprazole Lansoprazole Rabeprazole Pantoprazole Omepraz Side effects ole Some of the most frequent side effects of omeprazole are; headache, diarrhea, abdominal pain, nausea, dizziness, trouble awakening and sleep deprivation Proton pump inhibitors may be associated with a greater risk of hip fractures, and clostridium difficileassociated diarrhea Pantoprazole This medication may affect the results of certain lab tests (pantoprazole can cause a false positive for THC) … Lansoprazole Side effects Infrequent: dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus Rarely and very rarely: taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions Severe: Gastro-intestinal disturbances (such as nausea 1.3%, abdominal pain 2.1%, diarrhea 3.8%) … Rabeprazole Side effects he most common is headache in 2.4% of patients Diarrhea, vomiting, nausea, abdominal pains, Constipation, meteorism, dry mouth, increased or decreased appetite, asthenia, anxiety, vertigo, Sleeplessness, thrombocytopenia, Prokinetic drugs 7وكلوپراميد مت آنتاگونيست دوپامين است: بروز عوارض اكستراپيراميدال افزايش حركات قسمت فوقاني دستگاه گوارش اثر آن با آنتي كولينرژيكها آنتاگونيزه مي شود بعنوان افزايش دهنده ترشح شير Cisapride جانشين متوكلوپراميد ،بدون عوارض مركزي تحریک گیرنده های HT4-5و افزایش cAMP عوارض: ایجاد آریتمی جدی و گاها کشنده قلبی شامل؛ تاکیکاردی بطنی و فیبریالسیون بطنی … Domperidone Adverse Effects galactorrhoea or gynaecomastia: plasma prolactin increased Effects on the cardiovascular system: Sudden death , ventricular arrhythmias with parenteral products Extrapyramidal effects: such as acute dystonic reactions Colpermin Active ingredient: Peppermint oil Indications And Clinical Uses: For the symptomatic relief of abdominal pain, distension, flatulence and gas associated with the irritable bowel syndrome (IBS). … Colpermin Adverse Reactions: Reactions may include heartburn and hypersensitivity to peppermint oil or menthol, which is rare and includes erythematous skin rash, headache, bradycardia, muscle tremor and ataxia Not to be used in Children under 15 years of age Misoprostol Adverse Effects The commonest adverse effect of misoprostol is diarrhoea. Other gastrointestinal effects include abdominal pain, dyspepsia, flatulence, and nausea and vomiting …. Misoprostol Increased uterine contractility and abnormal vaginal bleeding (including menorrhagia and intermenstrual bleeding) have been reported. Other adverse effects include skin rashes, headache, and dizziness. Hypotension is rarely seen at doses recommended for peptic ulcer disease. آنتي كولينرژيكها مصرف اين داروها به دليل ايجاد خشكي دهان و كاهش حركات پريستالتيك روده ها محدود شده هيوسين ان-بوتيل برومايد دي سيكلومين پروپانتيلن كليدينيومC - بالدونا پي-بي عوارض جانبي آنتي كولينرژيكها 7ارض كالسيك آنتي كولينرژيكها عبارتند از: مهمترين عو تاري ديد ،احتباس ادرار ،ميدرياز ،خشكي دهان ،يبوست و تاكيكاردي عالئم مسموميت شديد با آتروپين عبارتست از قرمزي پوست :ناشي از ديالتاسيون عروق پوستي خشكي دهان :ناشي از مهار ترشح بزاق داغي :ناشي از جلوگيري از تعريق هيپراكتيويتي :ناشي از تحريك كورتكس مغز Antacids Side effects from antacids vary depending on individual and other medications they may be taking at the time. Those who experience side effects most commonly suffer from changes in bowel functions, such as diarrhea, constipation, or flatulence. …. Antacids Milk-alkali syndrome, which is serious toxicity and can be fatal Aluminum hydroxide: may lead to the formation of insoluble aluminium-phosphatecomplexes, with a risk for hypophosphatemia and osteomalacia Al(OH)3 + 3HCl → AlCl3 + 3H2O …. Antacids Magnesium hydroxide: has laxative properties. Magnesium may accumulate in patients with renal failure leading to hypermagnesemia, with cardiovascular and neurological complications Mg(OH)2 + 2HCl → MgCl2 + 2H2O Laxatives (also known as purgatives or aperients) Laxative Abuse: occurs when a person attempts to get rid of unwanted calories, lose weight. laxative abuse is serious and dangerous, often resulting in a variety of health complications and sometimes causing alth consequences of laxative abuse Upset of electrolyte and mineral balances. Sodium, potassium, magnesium, and Severe dehydration phosphorus may cause tremors, weakness, blurry vision, fainting, kidney damage, and, in extreme cases, death Internal organ damage may result, including stretched or “lazy” colon, colon infection, Irritable Bowel Syndrome, and, rarely, liver damage. Chronic laxative abuse may contribute to risk of colon cancer. شاد و سالمت باشید