مسیر سیگنالینگ سلولی JAK-STAT

مسیر سیگنالینگ سلولی JAK-STAT

اسلاید 1: JAK – STAT SignalingBehnaz BazrafshanP.hD student in Molecular Medicine

اسلاید 2: Janus

اسلاید 3: OverviewThe name of the JAK comes from a Roman two-faced god that implies two domains, including a catalytic domain and a kinase-like domain.JAK-STAT pathway has an important role in the control of immune responses Dysregulation of JAK-STAT signaling is associated with various immune disordersThe JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis.This pathway plays a prominent role in mediating signal transduction for many cytokinesJAK-STAT signaling is relatively simple, the signaling cascade consists of three main components: a JAK binding receptor, a Janus kinase (JAK) and signal transducer and activator of transcription (STAT) protein

اسلاید 4: JAK binding receptor Many cytokines and growth factors transmit signals through the JAK-STAT signaling pathway, including interleukins 2-7 (IL2-7), granulocyte-macrophage colony stimulating factor (GM-CSF), growth hormone (GH), (Epidermal growth factor (EGF), platelet-derived growth factors (PDGF) and interferons (IFN). Many cytokines and growth factor cytokine receptors can be divided into two groups: those whose intracellular domains exhibit intrinsic protein tyrosine kinase (PTK) activity, and those whose intracellular domains are devoid of such activity

اسلاید 5: Janus kinases (JAKs) represent a recently discovered family of PTKs that seem to play a central role in mediating signal transduction of many cytokines, and probably many non-cytokine regulatory molecules.Have four member : JAK1, JAK2, JAK3 and Tyk2 They all exhibit molecular masses in the region of 130 kDa and approximately 40% amino acid sequence homology.They appear to be associated with the cytoplasmic domain of many cytokine receptors, but remain catalytically inactive until binding of the cytokine to the receptor.