پارکینسون

پارکینسون

اسلاید 1: Molecular pathology of Parkinson’s Disease(PD)Behnaz BazrafshanPhD student in molecular medicine

اسلاید 2: CNS

اسلاید 3: Cerebrum

اسلاید 4: Brain Stem

اسلاید 5: Cerebellum

اسلاید 6: HistoryFirst Desciption of Parkinson’s disease.Surgeon GeologistPalaeontologistHe is best known for his 1817 work, An Essay on the Shaking Palsy, in which he was the first to describe paralysis agitans, a condition that would later be renamed Parkinsons disease by Jean-Martin Charcot. Dr. James Parkinson

اسلاید 7: Jean-Martin charcotNeurologist and professor of anatomical pathology.Charcots primary focus was neurology. He named and was the first to describe multiple sclerosis.Charcots name is associated with many diseases and conditions including: Charcots artery (lenticulostriate artery)Charcots joint (diabetic arthropathy)Charcots disease (amyotrophic lateral sclerosis, the most-common subtype of motor neurone disease—also known as Lou Gehrigs disease.)Charcot–Marie–Tooth disease (peripheral muscular atrophy), named with Pierre Marie and Howard Henry Tooth.Charcot–Wilbrand syndrome (visual agnosia and loss of ability to revisualise images), named with Hermann Wilbrand.

اسلاید 8: Jean-Martin charcotCharcots intermittent hepatic fever (intermittent pain, intermittent fever, intermittent jaundice, and loss of weight)Charcot–Bouchard aneurysms (tiny aneurysms of the penetrating branches of middle cerebral artery in hypertensives), named with Charles-Joseph Bouchard.Charcots triad of acute cholangitis (right upper quadrant pain, jaundice, and fever)Charcots triad of multiple sclerosis (nystagmus, intention tremor, and dysarthria)Charcot–Leyden crystals due to the lysis of eosinophils in cases of allergic diseases, named with Ernst Viktor von Leyden.Souques–Charcot geroderma: a variant of Hutchinson–Gilford disease, named with Alexandre-Achille Souques.[47]Charcot–Gombault necrosis: a biliary infarct, named with Albert Gombault.

اسلاید 9: What is Parkinson?It is neurodegenerative disorder characterized by the progressive loss of the Dopaminergic neurons in the substantia nigra pars compacta which innervates the dorsal striatum.