mRNA و microRNA درمانی

mRNA و microRNA درمانی

اسلاید 1: mRNA therapy1دانشکده :گروه:نام و نام خانوادگی :استاد:

اسلاید 2: معرفی سایت ها و پایگاه های داده miRNAو mRNA کاربرد های فعلی و موارد کاربرد احتمالی mRNA تراپی در آینده miRNA و RNAi چیست ؟؟منابع و مآخذفهرست مطالب ارتباط بینmi RNA و برخی بیماری ها مثل سرطانmRNA ساختار و نقش و عملکردو درصد هر کدام؟؟کاربرد در زمینه های مختلف و درمان بیماری ها با mRNAسرطان،دیابت ، آلزایمر،آسیب بافتی و ..(واکسن ) mRNA پیشگیری از بیماری ها با

اسلاید 3: What is mRNA ?Messenger RNA, or mRNA, plays a fundamental role in human biology, transferring the instructions stored in DNA to make the proteins required in every living cell. mRNA provides instructions to cells to make protein. 

اسلاید 4: 47,000 rare diseases that affect more than 300 million people worldwideAn estimated 30 million people in the U.S. are living with rare diseases.Yet, despite this high prevalence, there are approved drugs for only 5 percent of rare diseases and disorders.

اسلاید 5: 5mRNA base- Gene therapyhttps://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.genome.gov%2Fgenetics-glossary%2FGene-Therapy&psig=AOvVaw054F6yaN4Y82QsA-

اسلاید 6: 6mRNA therapy: A new form of gene medicineThe figure shows the main difference between mRNA and gene DNA therapy. You need to deliver mRNA only to the cytoplasm for it to work, while DNA delivery requires an additional, but a difficult step, of delivery to the nucleus. The difference between the two counts for both effectiveness and safety.Thereby, desired proteins can be produced in cells by exogenous delivery of IVT mRNA, which does not integrate into the host genome and results in transient production of target proteins

اسلاید 7: دسته بندی انواع RNA 7

اسلاید 8: Non-coding transcripts constitute a large fraction of the mammalian transcriptome8The GENCODE Project Consortium (http://www.gencodegenes.org/) and FANTOM5 (Chung-Chau Hon et al., Nature (2017) 543, 199–204 )The composition of non-coding transcripts in the mammalian transcriptomeHuttenhofer et al.

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