Nanographene oxide as a switch for CW/pulsed NIR laser triggered drug release from liposomes

Nanographene oxide as a switch for CW/pulsed NIR laser triggered drug release from liposomes

اسلاید 1: Nanographene oxide as a switch for CW/pulsed NIR laser triggered drug release from liposomes

اسلاید 2: LiposomesLiposomes have a long history as drug delivery vehicles and some liposomal formulations have been approved for clinical applications or currently are undergoing clinical trialsThermosensitive liposomes which are prepared with lipids having a higher phase transition temperature (transition from ordered gel phase to liquid-crystalline state) than physiological temperature (37 °C) can release their cargo in response to a mild hyperthermia

اسلاید 3: LaserThe light-triggered release is particularly attractive because it can be applied noninvasively with precise spatial and temporal controlnear infrared (NIR) light has gained increasing interest because of its relatively high tissue penetration and non-toxicityNear IR CW laser is mainly used for photothermal therapy of tumor tissues, but can also be used for on-demand drug release

اسلاید 4: Graphene oxideGraphene oxide (GO) is a unique two-dimensional (2D) nanomaterial with interesting physiochemical properties.GO also possesses a high photothermal effiffifficiency in response to NIR light, useful for photothermal ablation of tumor tissuesTherefore, GO can be an effffective candidate for NIR light-driven release from liposomes.