سیستم عصبی- سیناپس

سیستم عصبی- سیناپس

اسلاید 1: The Nervous System: General Principles

اسلاید 2:

اسلاید 3: CNS Synapses – types of connectionsAxodendriticAxosomaticAxoaxonic

اسلاید 4: SynapsesElectrical synapsesChemical synapsesactions of psychoactive drugscauses of mental disordersneural basis of learning and memory

اسلاید 5: Electrical synapsesIons can flow bidirectionallyConnexins that make up a connexon Pore size = 2nm

اسلاید 6: Presynaptic TerminalsTransmitter vesicles Mitochondria (ATP)Presynaptic membrane contains large numbers of voltage-gated calcium channelsTransmitter substance Excite or Inhibit Action potential2000 - 10,000 molecules of acetylcholine are present in each vesicleThere are enough vesicles in the presynaptic terminal to transmit from a few hundred to more than 10,000 action potentialsSynaptic cleft 20 – 50 nm wideSynaptic bouton Active zones

اسلاید 7: NeurotransmittersAmino Acidssynaptic vessiclesAminessynaptic vessiclesPeptidessecretory granules.Peptides may exist in the same axon terminals as amino acids and amines.Fast transmission uses Amino acids or ACh.Slow transmission may use any of the three types of neurotransmitters

اسلاید 8: Synthesis of peptide neurotransmittersSynthesis of amine and amino acidsNeurotransmitter Synthesis and Storage