Gram positive bacilli
اسلاید 1: GRAM POSITIVE BACILLI
اسلاید 2: Clinically important Gram positive bacilliSpore formingBacillusClostridiumNon spore forming1.Corynebacterium2.Listeria3.LactobacillusBacilli w/ branching filaments1.Actinomyces2.Nocardia
اسلاید 3: 1.BACILLUSBacillus anthracisHuman pathogenIsolation also considered to be clinically significantZoonosisBacillus cereusEnvironmental organismContaminates foodCommon cause of food poisoningBacillus stearothermophilusTolerates very high temperaturesUsed for quality control of autoclaves
اسلاید 4: a.Bacillus anthracisLarge bacilli of 1-3 mHistorical importanceSingle or paired in clinical isolatesIn vitro – prominent capsuleHighly resistant spores
اسلاید 5: Anthrax Pathogenesis and clinical presentations Virulence factorsCapsule(antiphagocytic)Toxin(oedema & death)Cutaneous anthraxAbout 20% mortalityGastrointestinal anthraxHigh mortalityInhalation anthraxHigh mortality
اسلاید 6: Anthrax - Epidemiology
اسلاید 7: Anthrax - Diagnosis SpecimenAspirate or swab from cutaneous lesionBlood cultureSputumLaboratory investigationGram stainCultureIdentification of isolate
اسلاید 8: Penicillin(Tetracycline /chloramphenicol)Erythromycine,ClindamicinePreventionVaccination of animal herdsProper disposal of carcassesActive immunisation with live attenuated bacilliAnthrax – treatment and prevention
اسلاید 9: b.Bacillus cereusLarge, motile, saprophytic bacillusHeat resistant sporesPre formed heat and acid stable toxin (Emetic syndrome)Heat labile enterotoxin (Diarrhoeal disease)Lab diagnosis – Demonstation of large number of bacilli in food
اسلاید 10: Gastroenteritis Bacillus cereus clinical presentationIncubation period < 6 hoursSevere vomitingLasts 8-10 hoursIncubation period > 6 hoursDiarrhoea Lasts 20-36 hoursEMETIC FORM DIARRHOEAL FORM
اسلاید 11: CLOSTRIDIUM (ANAROBES)AnaerobicSporingGram positiveDiameter of the spore is larger than the cell resemble a spindleClostridium is derived from Kloster meaning spindle
اسلاید 12: Spores Pleomrhic (elongated, spindle)Most are obligate anaerobes produce neurohisto toxins
اسلاید 13: Saprophytes - MostSome are opportunists - tetanus/gas gangrene/food poisoning Cl. perfringens - commensal of the intestineCl. sporogenes - -do-Can invade the intestine after the death
اسلاید 14: CLASSIFICATION BASED ON THE TYPE OF DISEASE PRODUCED A . Tetanus Cl. tetani - Present in soilB. Gas gangreneEstablished Cl. perfringens ‘gut’ organism Cl. septicum Cl. novyi- Less pathogenic Cl. histolyticum Cl. fallax- Doubtful Cl. bifermentans Cl. sporogenes
اسلاید 15: C. Food poisoning 1. Gastroenterritis - Cl perfringens Type A2. Botulism - Cl. botulinum/ Soil 3. Pig-bel Cl. perfringens type CD. Acute colitis - Cl. difficile / gut’ organism (pseudomembranous colitis)Commonest cause of ‘nosocomial’ diarrhoea
اسلاید 16: GAS GANGRENE
نقد و بررسی ها
هیچ نظری برای این پاورپوینت نوشته نشده است.