Supramolecular Chemistry and Homeopathy

Supramolecular Chemistry and Homeopathy

اسلاید 1: www.tabaye.ir

اسلاید 2: BEYOND THE MOLECULE:TheoryEvidence Biological Physical Structure Action Supramolecular Chemistry and HomeopathyACTION

اسلاید 3: Clathrate Model

اسلاید 4: H2O= 1 oxygen, 2 hydrogen atomsELECTRONSOXYGENATOMHYDROGENATOMHYDROGENATOMELECTRONSSharedelectrons

اسلاید 5: H2O qualities The water molecule is a small molecule. Oxygen=sharp, H2O penetrates, universal solvent. Oxygen atom is analogous in shape to a tetrahedron, which gives it four connecting joints. Two of these connections hydrogen atoms are bonded, which gives the water molecule a positive and negative end.

اسلاید 6: How water structuresWater molecules form around an ion according to its shape and magnetic signature to create an ionic macro Negative polePositive poleCybotactic fieldOuter hydrate shellInner hydrate shellOuter hydrate shell extends to next cybotactic shellAqueous macros

اسلاید 7:

اسلاید 8: 2010 scientific anniversary200th year anniversary of Avogadro’s Constant (1810)Davy and Farraday recorded evidence of liquid aqueous structuring (1810)Mendeleev observed aqueous structuring1910 Johannes van der Waals wins the Nobel prize for his descrition of intermoclecular forces, what holds this aqueous structuring together.

اسلاید 9: Clathrate hydrates1940’s named “clathrate” = “cage” or “lattice.”Double Nobel laureate Linus Pauling speculated clathrates have biological effects1950’s French researchers Gay and Boiron discovered homeopathic solutions have dielectiric stress indices1960’s Barnard - intermolecular forces key to liquid structuring.1990’s Anagnostatos proposes Clathrate Model

اسلاید 10: Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA SequencesIdentifies both structure and EM signal from high diluteIdentifies “cross talk”Validates homeopathy physically and electromagneticallyVindicates BenvenisteLuc Montagnier, winner of the Nobel prize for Science and Medicine

اسلاید 11: Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA SequencesAbstract: A novel property of DNA is described: the capacity of some bacterial DNA sequences to induce electromagnetic waves at high aqueous dilutions. It appears to be a resonance phenomenon triggered by the ambient electromagnetic background of very low frequency waves. The genomic DNA of most pathogenic bacteria contains sequences which are able to generate such signals. This opens the way to the development of highly sensitive detection system for chronic bacterial infections in human and animal diseases.

اسلاید 12: Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA SequencesSignal producing dilutions usually ranged from 10-8 to 10-12, with profiles upon Fourier transformationIn one experiment, some very high dilutions were found positive, ranging from 10-9 to 10-18.Filtration demonstrated aqueous structures had a size greater than 20 nM and lower than 100 nM.Why were the lower dilutions “silent?”Silent low dilutions maybe self-inhibitory from interference of multiple sources emitting same wave length or slightly out of phase, like radio jamming . . or the abundance of nanostructures can form a gel in water and therefore are prevented to vibrate.

اسلاید 13: Evidence for homologous “cross talk” between dilutionsIs it possible wave transfer to generate new signal-emitting structures from tube to tube?A tube of a low “silent” dilution of E. Coli (10-3) was placed side by side close to a receiver tube of the positive “loud” highest dilution of the same preparation (10-9). Both tubes were placed in a mumetal box for 24 hours at room temperature, so that the tubes were not exposed to external electromagnetic noise, and only exposed to the signals generated by the structures present in the tubes themselves.Tubes were read again by the signal detecting device: the donor tube was still silent, however the receiver tube became also silent.

اسلاید 14: #2 Evidence for homologous “cross talk” between dilutionsWhen further dilutions were made from the receiver tube (10-10, 10-11, 10-12), these dilutions had became positive. These results suggest that the receiver tube was made silent by formation of an excess of new nanostructures, which could emit signals upon further dilution. Surprisingly, the range of positive dilutions were not strictly dependent on the initial concentration of E. Coli cells, being roughly the same from 109 cells down to 10 cells, suggesting that the same final number of nanostructures was reached at all concentrations. Thus, paradoxically, 10 cells are giving the same signals than 109 cells.

اسلاید 15: ALL HOMEOPATHIC STUDIES ARE FOR VERUM!NO EVIDENCE FOR PLACEBO!NO PROTOCOL FOR PSYCHOGENIC TESTINGVERUM TWISTED, DISMISSED, DENIED OR REINTERPRETED TO ASSERT PLACEBOPRE-CLINICALS DESTROY PLACEBO HYPOTHESISLilli Kolisko

اسلاید 16: Evidence of actionPre-clinical & clinical evidence cannot be reasonably denied. 200 years clinical, common use , clinical reports should be convincoing of efficacy. Prima facie composition of the substances used contradicts common sense of biological action. Critics assume users of homeopathic are unaware of lack of active molecular content & conclude that effects are psychogenic.William E. Boyd, M.D.“The Biological and Biochemical Evidence for the Homeopathic Remedy,” Boyd, 1954

اسلاید 17: Homeopathic myths“There is no science to back up homeopathy.”“There are no double blind trials for homeopathy.”“Homeopathy is fraud”“Homeopathy doesn’t work.”“Liquid water can’t structure”When there aren’t molecules of the active agent left in solution there can’t be biological effects. (Ennis) Homeopathy is a placebo”

اسلاید 18: Biochemical studiesHomBRex database specializing in homeopathy research as of February 2009 contained 1301 experiments in 997 original articles including 1172 biological studies.Witt 2007 established criteria for evaluating homeopathic research: Score for Assessment of Physical Experiments on Homeopathy (SAPEH) SAPEH scored each test 1 -10: Objectives, controls, blinding, randomization, consistency, experiment standardization, statistics and resultsWitt evaluated 67 experiments (1/3 of them replications).3/4 found effect, Nearly 3/4 of all replications were positive.

اسلاید 19: Six types of biochemical (in vitro) tests for homeopathy 1932-2005 Non celluar systems – 17: 15 positve, 2 negative Cultured cells – 13 : 5 positve , 8 negative Erythocytes – 2 positiveBasophile granulocytes – 28 : 23 positve, 5 negativeNeutrophile granulocytes – 2 : 1 positve, 1 negativeLymphocytes – 4 : 3 [postive, 1 negativeEugene Kolisko

اسلاید 20: Basophil degranulation testFirst introduced by Murietta in 1985First successful degranulation, Poitevin, 1985First reproduction by Sainte Laudy and Belon 1986Davenas, 1988, Nature article, first widely publiszed results in a major science magazine.Benveniste 1991 ninth positive replicationBelon, Ennis et al 1999 multi centered trialSainte-Laudy, Belon “Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutionsEnnis calls for new multi cnetered testDr. Jacques Benveniste

اسلاید 21: Social dimensionsWorld’s most prevalent modern internal medicine Second only to traditional Chinese in usageFounder left behind doctrine of work that treats anyone with any problem 100,000 case notes, Expanding materia medica Widow less than half his age. Not solely psychogenic (placebo) so we have to look to physical causes for the answer. Dr. Samuel Hahnemann, Our Founder

اسلاید 22: Two types of chemistryTraditional chemistry, used by the big pharmaceutical companies to create modern patented drugs.Second chemistry known only fifty years, supramolecular chemistry. Branch of chemistry that explains homeopathy. The missing link to the science of homeopathy.The best explanation for the homoeopathic remedy. Supramolecular chemistry is the study of an organization of two or more molecules held together by intermolecular forces.

اسلاید 23: Supramolecular chemistrySupramolecular chemistry = best explanation for homeopathy. Supramolecular chemistry is the study of an organization of two or more molecules held together by intermolecular forces.Supra means “beyond.” Supra molecular means “beyond the molecule.”Fits homeopathy beautifully: homeopathic substances are “beyond the molecule.”

اسلاید 24: The Clathrate HydrateClathrate is the active ingredient of the homeopathic remedyClathrate model now validated by the material sciencesRoy 2005 Structure of Liquid Water; Novel Insights from Materials Research; Potential Relevance to HomeopathyProfs Rick Hoover of Penn States material sciences dept; Iris Bell, MD, University of Arizona’s dept . of psychiatry, Professor Emeritus Rustum Roy.Roy’s most comprehensive presentation for liquid aqueous structuring as the basis for the homeopathic remedy. Specifically names the clathrate

اسلاید 25: Clathrates go by many namesClathrate hydrates are also called gas clathrates or gas hydrates, inclusion molecules or cage molecules.Clathrates are forms of structured water, crystalline water based solids that look like polyhedral ice crystals. Molecules trapped inside hydrogen bonded crystalline water cagesFormed through host guest processTREE OF LIFEChakras

اسلاید 26: Biological effects and physical properties of clathratesThe world’s only person to win 100% of two Nobel prizes, chemist Linus Pauling, claimed clathrates are what give alcohol its narcotic effect. A recent American-Russian study revealed that the taste in alcohol is due to its clathrate content and were able tomeasure the difference teween lower and higher priced vodka.The battery industry is studying their use as anodes.Clathrates are being studied as superconductors because the hollow cage structure conducts little heat

اسلاید 27: Traditional vs. supramolecular chemistryTraditional chemistry focuses on covalent bonded materialCovalent bond, atoms share electron, locks atoms together to become moleculesPatent medicine uses covalent bond to synthesize petro chemicals for medicineHomeopathic medicine uses hydrogen bond to create the substances it uses as medicineSupramolecular replaces covalent bond with intermolecular forces, i.e. hydrogen bondTo understand how clathrates form and how they create their biological action, we have to take a look at the water molecule. Rare photo of clathrates forming around contaminaaints in the atmosphere. Also called parhelia, sun dogs or the Eye of God

اسلاید 28: The Hydrogen BondIonic StructuringThe Host/Guest Process Clathrate HydratesThe Nanobubble - Air Nucleation & MimicryHow Water Structures

اسلاید 29: Theory supported by 200 years of direct observation by scienceWe know liquid aqueous structuring exists from 200 years of direct observation (Davy, Farraday, Mendeleev, Sukul, Rao, Roy, Tiller, Montagnier et al et al)The tetrahedral shape and dipolar charge make H2O molecular self-assembly inevitable. Water has to structure. The strength of the hydrogen bond can be seen in surface tension, strong enough to float a paper clip.H2O structuring will conform to exogenic forces  Ionic contamination, in the host guest process, concentrates H2O into clathrate hydrates, crystalline structures that gridlock around ions, imitative of their charge and structure.Ionic nucleation is replaced by air nucleation, what Roy calls nanobubbles.Sir Humphry Davy, first described the clathrate in 1810

اسلاید 30: HOMEOPATHY FOR FARM AND FARM AND GARDEN by Vaikunthanath das Kaviraj HOMEOPHYTOPATHOLOGY: The use of homeopathics for plantsTHE GREAT PROVING

اسلاید 31: Structure of the remedyWater molecule tetrahedral in shapeBasic universal building blockSmall enough to enter lattice work of compounds and attach itself to their positive or negative ionsH2O’s assemble according to the ion’s shape and charge

اسلاید 32: Structural gridlockWater structures are made via the hydrogen bond, not the covalent bond.Hydrogen bond = 9 nanosecondsOpponents say, liquid aqueous structuring then, can last only briefly BUT . . What is the duration of separation? Structure is gridlocked!Where does the connection go next? IT SIMPLY RETURNS!Liquid aqueous structures are vibrating.

اسلاید 33: Host guest process Molecular self assemblyWater will naturally structure when it is given something to structure around. Nucleates around the smallest hydrophobic unitIonic nucleation is replaced by air nucleation during succussion, what Roy calls nanobubbles.The entire solution is inlfuenced by the strucutre. No water molecule goes untouched in the solutionWhen guest molecules thin out in dilution, they are replaced by supramoelcular structuring

اسلاید 34: How Nat Mur is made - dilutionWhen salt is added to water, the smaller H2O molecules seep into the lattice work of the compound Negative poles of H2O molecules are attracted to the positve charge d Na+ ion, and the positive poles to the negative charged Cl- atom to form the inner hydration shell A second organized field of organization, the cybotactic region, forms around the inner hydration shell Organization continues outward to the closest magnetosphere

اسلاید 35: How Nat Mur is made - succussionDuring succussion, atmosphere is introduced into the solution and pressurizedHydrogen bonds intensify around atmosphereSurface tension in water from hydrogen bonding strong enough to float a paper clip

اسلاید 36: Transitional nucleationThe five transitional states, from quintessence (ether) to fire, from fire to gas, from gas to liquid, from liquid to solid matter and back, is continuous - Johannes van der Waals, Nobel prize for intermoelcular forces, 1910Intermolecular forces control the material characteristics of all phases of matter. In the homeopathic supramolecular solution, ionic particle nucleation is replaced by a ionic air nucleation

اسلاید 37: 12 physical testsDielectric strength: 6 Galvanic effects 5 Light absorption spectra: 4 NMR: 18 Raman spectroscopy: 7 . Black boxes: 4Gas discharge visualization 1Polarized photography 1Beta scintillation 1 Radio reception 2Thermoluminescence 1Capillary action

اسلاید 38: PHOTONIC HOMEOPATHYDelivering the remedy via lightShining a light through argentum metallicum conveyed its anti-bacTerial qualities to the receptorIntroduced in “On Chemical Medicine, Thermodynamics, and Homeopathy” by Prof. William Tiller of Stanford UniversityWhat’s next?

اسلاید 39: QuestionWhat physical characteristic of the homeopathic remedy controls potency?

اسلاید 40: AnswerPROPOSAL: Dilution increases the frequency, resolution coherence of the signal. Succussion increases it’s amplitude

اسلاید 41: What gives the homeopathic remedy its biological action?Question

اسلاید 42: AnswerAnswer: The electromagnetic signal. Propsoal: Lower frequency signals from covalent bonded matter have a shorter broadcast range and talk to the system on a localized basis. The disease state arises from trying to act on a localized basis. The lower signals drown out the higher source signals. In the homeopathic remedy the lower source signals have been removed by dilution, and the higher signals of the source replicated and amplified,. The body recognizes the disease state systemically from the higher signal

اسلاید 43: QuestionIf a skeleton comes to you to be cured of alcoholism, what remedy do you give him?

اسلاید 44: AnswerPulsatilla and a mop.

اسلاید 45: Thank you!

اسلاید 46: Special thanks to Dr. Shashi Sharma and the Hahnemann College of Homeopathy Beyond the Molecule 2010 with John Benneth