کانال پروتئینی سلول

کانال پروتئینی سلول

اسلاید 1: Nongated ion Channels and the Resting Membrane PotentialIn addition to ATP-powered ion pumps, which transport ions againsl their concentration gradientsthe plasma membrane contains channel proteins that allow the principal cellular ions (Na+, K+, Ca2+, and Cl-) to move through them at different rates down their concentrarron gradients.

اسلاید 2: E= - 61* log Ci NaCo NaE= - 61* log (0.1) E= - 61* (-1)E= 61 mvE= - 61* log14140پتانسیل تعادل سدیم+ + + + + +

اسلاید 3: پتانسیل تعادل پتاسیم

اسلاید 4: E = -61 Log PNa * Ci Na + PK * Ci K + PCL * Co Clمعادله گولدمن – هاجکین - کاتزPNa * Co Na + PK * Co K + PCL * Ci ClE= -86 mv

اسلاید 5: -4 mv-86 mvE = -90 mv

اسلاید 6: Action Potentialپتانسیل عمل

اسلاید 7: lon Channels Contain a Selectivity Filter Formed from Conserved Transmembrane SegmentsAll ion channels exhibit specificity for particular ionsComparisons of the sequences of other K+, Na+, and Ca2* channels established that all such proteins share acommon structure and probably evolved from a single type of channel protei