صفحه 1:
-
ب
“ ۴ 6 22
صفحه 2:
Introduction to Ayurveda-
Safety Aspects of Herbo-
Metallic Compounds-Rasa
Aushadhi of Ayurveda
صفحه 3:
Ayurvedic approach of Health
Ayurveda is a name which the Ancient
Indians gave to their science of medicine.
Ayuh means life and Veda means
knowledge. Therefore Ayurveda is a
science by the knowledge of which life
can be prolonged and its nature can be
understood. In a broader sense, Ayurveda
like Dharma (religion) is ۱:۱۹
decompartmentalized; it includes the
adaptation of customs, traditions, ethics,
hygiene and medicine.
صفحه 4:
Subject Matter:
The fundamental concept is mainly
based on Samkhya and Nayaya
NETS att) a) system of Indian
philosophy. Subject matter 15
scattered in Vedas, Upanishads and
other Classical literature.
Charaka Samhita, Sushruta Samhita
and Ashtanga Samgrah are three
important Medical Texts.
صفحه 5:
Ayurvedic concept of Health is based on
Tridosha Theory. Tridosa is biological
entity responsible for structural,
functional and behavioral dimensions of
the living organism.
QOoskes we tw pes =
cab ee Cae ACP SNe eS A DAN] رز( سا
کم ره با
صفحه 6:
02610000 6000260 11
صفحه 7:
GIGOIP1IC@OCE OP PROKRIM 10
OCLIDIC@L DEM10106
2 Prowetve Weatk
fo) ese od Den
A RO يي ل Ca aS Od
(Prabrii)
DA aS La ل
7) Course, Orwpiiraiva ard Dbiczate
1 oN cn
d) Onog body isteraciiog
صفحه 8:
WESLTH BOO ل ا لل نا
0166662
(ORC res
۱
9
0 2
ا أت
ا 00
0 0
۱ سم تا رصم ad
مت hac acc اه ی سم
تسم پر للك الت
مر(
صفحه 9:
Ayurvedic approach of therapy
Creed
مر و۱
Curative
Sin USN eA CA Da eeu gece OD) PR cence a ca
سال جار Nel Past ۱ ast ۱/۵ ۱
0 ل UAC Ne) Zac
صفحه 10:
ii. Pharmacologic: plant based single and poly
herbal preparations.
Herbo-metallic preparations:
Bhasma: Powder of a substance obtained by
calcination is called Bhasmas. It is applied to
metals and minerals and animal products
Rasa-Yoga: Preparations containing minerals as
main ingredients are called Rasa-yoga. Abhrak
(Mica), Makshik (copper-pyrites) , Swarna (gold),
Rajat (silver), Tamra (copper), Kamsya (Bell metal)
ات
Rasa Aushadhi: Preparations containing metals,
minerals are considered rasa-aushadhi:
صفحه 11:
Guphur & Copper or مها ترا هه سم ها
تحاسم دس متا دماح هرت
we yeverdly toxic to tts waive Pore.
® Geverd webwds hwe ber desorbed Por detoxPicuica oP wet
متا مت ae eae
© Qorncectiva of the clossicd preparaicn doy wits their top edicts
focludiag history oP use.
td ها بسا سس متا سم سم ما
تسم وت
لل الل 0
pornvrers.
a همم راد مرا aE naa ae
شم متس میت
صفحه 12:
الك 0۱( ۱۲۱۷ ۳
characterization
Distribution, Bio-transformation and
Route of Pere ات ولا الل
Vapor, sub-
cutaneous and oral.
boys dal Via toda) 4
Distributes widely to all
tissue, kidney, liver
spleen and CNS.
یروت : 0(
by Urine and
fecal Interact with
different enzyme
55 1۳ t=)
bodv in Presence of
صفحه 13:
WHO Limit
Normal permissible
50.175 pgm/Lit.
ote COLL
Heavy Metals Blood
Mercury 0.2-3 ng/ml
8الوت و۱ 1.1 ugm/Lit.
۳ 0.02-1.0 .لاون
و۰۰[ 100-200 ygm/dl
Aluminium 1-10 اموه
Nickel 0.05-1 ng/ml
Magnisium 1.8-3 mg/dl
Zinc 50-150 ugm/Lit.
(وویل
صفحه 14:
Rural
1.0
29
Normal and obtained level of
elements in blood and urine
Urine (g/dl)
Norm | Obtained Value
al
مومءن | عنااقلا
23) 2.9
25 5.8
84 92
54
Blood (g/dl)
Obtained
Norma Value
| Value
Urban | Rural
2.0 shld 0.96
2.9 6.5 99
3.10 | 3.98 1.96
Elemen
5
Mercur
الا
۱220
Arsenic
صفحه 15:
Experimental Animal Study
Dose of Makardhwaj
Makardhwaj: (i) 50 mg/kg
daily ۲ 5
Preparation of Makardhwaj as per classical
method (Rasa Tarangini ) human dose
125mg to 250mg/day
00 - ۱
Mercury - 4 part
Sulphur - 8 part
Maximum Human Dose= 250mg/day ; Average Human
Wt=50kg
Per Kg Dose=250/50=5mg ; Animal Dose ten Times more
صفحه 16:
ACUTE TOXICITY OF MAKARDHWA)
PU Cel et ae)
Mortality after
24+ ۰
0/6
01
0
0
01
0/6
Sample size
لك الكت الكت الكت الكت الكت
01
(mg/ kg)
50
100
150
200
250
300
No lethality was found at the highest dose of
300mg/kg/day
صفحه 17:
Neurobehavioral toxicity following Makardhwaj
(Dose 50 mg/kg)
ات را
تین
5
1
Observations
After 12
ey
۳
5
+
+
5
5
6 ۲۵۲
لهلنا
+
7
+
+
b,
fy
abnormality was observed
following oral administration of Makardhwaj
Tahal
5
a
Tests
۱۴۱۵۷9
reflex
Grasping
لتلییدی
reflex
Equilibrium
Head
shaking
Auditory
CM ee) tr Cle
صفحه 18:
Chronic Toxicity of
Makardhwaj:
Chronic toxicity of studies were carried
out among albino rabbits of Holland
strain with average body weight of
1.86+0.58kg upto 3 months.
The dose of Makardhwaj was
50mg/kg/day
No adverse effect on hemopoetic,
Gastro-intestinal, Hepatic & kidney
function test were noticed.
صفحه 19:
jormal Micro angiography of the Kidney
Right Kidney Left Kidney
صفحه 20:
زا وقمط و/وه 2.5 راو
١ قوط وعارود 12.50 زدسحطلعطكة
Dose 2.5 mg/kg body Wése 5.0 mg/kg body;
D از
رای سیب Damage with HgCl, Makardhwaj
2
ists (High Dose) +HgCl,
صفحه 21:
Effect of Makardhwaj on serotonin level
ا ال اوت اذا
رولیت نوت
Hippocampus
14 days
0.364
2 3
1۳۹۹
2-0064
ان ع0
0.075+
Frontal Cortex
14 days 7 ۷5
208 0.362
+ 0.075 + 0.092
0.364 1۳۳۹۹
ات +0.042
P>0.05
(۳ Selo} ع0
2-072 +0.065
0 ا
۸۰
0.2
+ 0.088
0۳۹۵
+0.061
No.
of
anima
10
10
10
Treated
Group
Normal
ener)
(Cea as
Makardhw
3 300
mg/kg
9
اس را
P30.05
100 mg/kg
تا
صفحه 22:
Beneficial effect of Makardhwaj on nor-
adrenaline in experimental rats
nor-adrenaline(p gm/gm tissue)
Mid brain
۰/1 14 ۷5
0.621 0.631
نر ركه + 0.085
0.408 0.402
+0.039 +0.061
roa OSI)
+£0.098 +0.090
۳>1
Total brain
7days |14 days
01 |
20067! ١ و00
0222 0.216
+0.045 | +0.051
0
Pec) Sen ese
P<0.01
Treated | No. of
Group animal
10
10
سس
لت
اليك
Makardhwaj
300 mg/kg
3
Makardhwaj
0 3 a
صفحه 23:
Effect of Makardhwaj on Dopamine level in
6۵۵۲۱۱۵۱۲۵۱ 5
زرا )ریا ۱۱۰/۰
Mid brain
۷5 14 ۸۰/1
1.208 1.272
0.088+ 0.092+
1.108 1.156
حاف عه 2-24
1.283 1.289
20.98 ۱2
الل
Total brain
7days |14 days
OR is} 202,22
20.082 |] 4
0664 0.641
20.050 | +3
0 0.858
28010005 | 4خ
065 حم
P<0.001
Poe ea
و۱
20۱۳۱
10
10
10
5
دض
Treated
Group
لسن
أ5عة) امتاومى.
Er
Makardhwaj
mg/kg 300
3
Makardhwaj
100 Nol ند
fds
Se aad
یت
صفحه 24:
Effect of Makardhwaj on choline- acetyl-
transferase in experimental rats
ChAT activity (n mol/mg
protein/hour)
Hippocampus
14 days
19.88
220
14.06
Eocene)
(۳
2-2
7 days
(۵
3212
ْ2ى1ظ1
3.01+
eis
الل
Frontal cortex
5لاة0 14
22.7
231
alco)
ead ital
PANS)
2294
7 days
۳/۵
ع
9-21
2۳0
4.
۳
P<0.001
000
۱
20۱۳۱
10
10
10
5
دض
Treated
Group
لسن
عأ5عه) امتأوى.
Et al
Makardhwaj
mg/kg 300
3
Makardhwaj
100 مه 8/06“
ات ORC)
و
یت
صفحه 25:
Mahayograj guggulu (with silver &
makardhwaj) is an Ayurvedic herbo -
metallic preparation mainly advocated
in the management of Rheumatoid and
Osteo-arthritis.
Heavy Metals ug/gm of the product
(JAMA) (SASTRA & BHU)
ات۷۹ 5 37000 22000
Mercury : 22800 23800
Arsenic: 8100 6200
Presence of Organic materials
صفحه 26:
تسه as RCO LY oes ا
تک لال
صفحه 27:
Sem of Mahayograj guggul (with
silver and Makardhwaj)
] eee oC ee eee
صفحه 28:
Acute toxicity of Mahayograj guggulu (with silver &
Makardhwaj) Animal model: Charles Foester Strain
rats.
Dose Move Mortality after
(mg/kg body Sample Size
72 ۰
wt.)
250 6 0/6
500 6 ۸0
1000 6 ۸0
1500 6 ۸0
2000 6 0/6
صفحه 29:
Neurobehavioural acute toxicity following Mahayograj
Guggulu (with Silver & Makardhwaj)
After 72
es
ay
te
(Dose 250 mg/kg body wt)
Observations
After 24 After 48
es es
+ +
+ +
+ +
+ +
+ +
+ +
Initial
دحالا
Flexing
reflex
Grasping
reflex
Corneal
Kail
Body
equilibrium
Head
shaking
Auditory
صفحه 30:
Chronic Toxicity of Mahayograj
Guggulu (with silver &
Makardhwaj)
Chronic toxicity of studies were carried
out among albino rabbits of Holland
strain with average body weight of
1.90+0.55kg upto 3 months.
The dose of Mahayograj Guggulu (with
silver & Makardhwaj) was
250mg/kg/day
No adverse effects on hemopoetic
Gastro-intestinal, Hepatict and kidney
Fn SN EAE! eet en gee mT Se Eh Tee.
صفحه 31:
Changes in Acetylcholine concentration following
oral administration of Mahalaxmivilas ras with
gold mahayograj guggulu with gold & Mahayograj
guggulu with silver & makardhwaj
Acetylcholine Concentration (n mol/g)
28
aa
262
2705
25.72
£1.82
22.60
2213
19.5
PRL}
Eien
14
008
27.42
42
2645
2211
2365
۳
20.74
+£1.20
ادنانما
28.82
2196
er
0
2432
£2.10
2232
2160
18.62
2162
152
21
2 0
214
23
23.42
+£1.02
262
2105
175
+£2.01
165
2182
Initial
24.82
اكه
لیوا
یعس
۸(
/كم6 وا
.اللا
50 /و
remy
vis
7
/كدط و6
cr
1122127
i
TESS
یت
ie)
Mahayoor
a
تاناوونه؛
۱
DEN rg
3
ی
تن
3
Makardhw
ل
صفحه 32:
28
aa
0
+£0.030
0261
61
0525
2025
0.420
+£0.021
Changes in nor-adrenaline following oral
administration of Mahalaxmivilas ras with gold
mahayograj guggulu with gold & Mahayograj
guggulu with silver & makardhwaj
کی ا ا
Eien
14
008
0.689
20043
0.269
۳
20
02
0425
2005
ادنانما
0671
205
er
0
0.386
20062
0342
+£0.040
0271
20041
0.235
۳۹
Frontal Cortex
214
23
932
059
0.352
+£0.50
0262
2105
0.240
+£0.071
Initial
0.375
2042
لیوا
یعس
۸(
/كم6 وا
.اللا
50 /و
remy
vis
7
/كدط و6
cr
1122127
i
TESS
یت
ie)
Mahayoor
Guggulu
uggul
anes
DEN rg
3
1
ی
تن
3
Makardhw
ل
صفحه 33:
28
aa
1282
+£0.102
1.230
2062
1223
+£0.102
0.980
Exes
Changes in Dopamine following oral
administration of Mahalaxmivilas ras with gold
mahayograj guggulu with gold & Mahayograj
guggulu with silver & makardhwaj
(عنددا تمو/وي) عمتمدمهه
Eien
14
008
1265
2
1.235
20072
1.025
2005
055
2002
ادنانما
1.245
+£0.120
را
aA
0905
20065
0.845
06
0715
۳۹
0.630
20042
Frontal Cortex
214
23
09872
2105
0.832
+0.040
0,25
2
0.645
+£0.060
Initial
0.860
0025
لیوا
یعس
۸(
/كم6 وا
.اللا
50 /و
remy
vis
7
/كدط و6
cr
1122127
i
TESS
یت
ie)
Mahayoor
Guggulu
uggul
anes
DEN rg
3
1
ی
تن
&
Makardhw
ل
صفحه 34:
Clinical Study
Procedure:
27 cases (14 male & 13 female)
receiving Mahayogaraj Guggulu with
silver & Makardhwaj in the dose of 2 tab
twice in a day prescribed by qualified
Ayurvedic physicians were selected.
The cases receiving the therapy
were carefully monitored for adverse
reaction on different system.
Three successive follow-up studies
.ناه 0م3111» عاع نلا
صفحه 35:
studies oP the subjevts لك
Cudvaica of Ourovcgrd quyquu (ik siver & Ockadhwd) oa
ا ا اا ا
a
یه
00
®@O Pro
ees) 40.08 (0
000 ۵و 6.66 90
ات 19 3 HOO
56 225 0
eo} 299 0 00
OFS 2 2:0
ced) oe
اس مات 0 Paes)
0.95 0.06
سم 00 0 00
Kors} 006 aos
‘Wb (%) 46.09 مد 6 00
صفحه 36:
CT atm Lent an BOO UNE OT ae Load
Nee aoe
]9 سامت
سس
oe eee Coe
Ose 6.66 09 قات
Bn 00 20.70 +£9.00 2020
Gee ۹۹۹ 5۳ 55۳
ie ۳ مد مد
0606.66 006 6م 656
66د ۵00 Prive) رطان رضم
60000 #0.09 9009 =
ee) 666 0 +00
0.69 0.99 0.68 0
(Gai) 06 40.00 06
OS Kier ated 9900 06060 9.99
رت( امد .#0 )%
صفحه 37:
اس مهو پم هت وم ها سا مت
ات مه میت
۵۲ 6 علب
ere)
66م
rime)
Pans
26266
2000
exer}
0۵۵
099
00
عصصصعت عطاطنععی
۹
Ses
era)
200
137
PO
008.68)
0
CST)
40.00
Carre}
606
2
7
00
oe)
(0
60.66
206.6
3.08
40.90
ان
200.66:
ed
KOC)
Cee)
۱
Coe ene
۳
a
oe
(لسنت)
صفحه 38:
Level of lead in blood and urine following
oral administration of Mahayograj guggulu
(with silver & makardhwaj) in rheumatoid
arthritis cases
80 7
70 +
60۰
gro مه 8106
۳۳۹
Initial 1۱ ra eo
Normal range - In Blood <29 ugm/dl
In Urine < 2.3 ugm/dl
صفحه 39:
Level oP wercury ta blood dod له
رس bP Oudkayrgra quecqutu (wits siver &
سم میا مس ما هت
- 25
3
3
ع
: 15
ا
[ 10
=
3 3
سلتة 8
re
۳۵5 3 ۲هاگ كلامم" 2 ععناقم ییا ترا ادنالما
هر رت ویر ۱۱
01 ينك عي لين" نا
صفحه 40:
Level oP @rseur ta blood ved کم هت رس ها را رم
مس مه معط میس رما
- 0 01
-« ald
After month — After 2months —_After 3 months لسن
Normal range - In Blood < 3.0 ugm/dl
In Urine < 8.4 ugm/dl
صفحه 41:
-« ۴
- 000
Gheoicaiog oP lead oer
سر رصم رما وت
-: رهم و ا
ادا سس
06 1 اه
After 7 days
Initial
]<
ابیز
صفحه 42:
Conclusion
™ Ayurveda has adopted holistic approach. It
includes the entire spectrum of life.
™ The object is to enhance longevity.
™The application of fundamental principles of
Ayurveda is helpful in the prevention and
Management of various mental and physical
disorders.
™The non-pharmacologic procedures include
observance of good conduct and practice of
relaxation, meditation and other yogic practices
in order to maintain the positive health.
Ayurveda various metal and minerals are ما"
used for the prevention and management of
various diseases. The metals are modified in a
new compound which have therapeutic
potentials.
صفحه 43:
0 ,بصیل) (OTE OU a i:
Prof. روت رم
Centre for psychosomatic & Biofeedback Medicine
&
Deptt. Of Basic Principles, Faculty of Ayurveda, IMS, BHU
&
Centre for Advanced Research in Indian System of Medicine,
SASTRA, Thanjavur